Chasetown made a positive start on a tricky surface but a Liam Holt effort way over the bar was their sole attempt in an otherwise one-sided game.
Ryan Wynter had the ball in the net but that was quickly ruled out for an offside against Mitch Piggon.
Gresley lost their goalkeeper Robert Peet to a painful leg injury that stopped the game for eight minutes until he was stretchered off.
Gresley took a shock lead when Josh Ruff conceded a penalty and Thomas Manship fired the kick in off the post with Curtis Pond diving the right way.
Jack Langston was a fingertip away from equalising with a free kick from the edge of the box that makeshift keeper Matthew Melbourne was equal to with a spectacular save.
The Scholars Ground Church Street Chasetown Staffordshire WS7 3QL View with Google Maps
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