Gladiators are looking to bounce back after a 34-20 defeat at home to Blackpool Scorpions last time out.
Injuries mean Craig Jones, Dave Beddows and Terry Toland will miss out but there are returns for Olly Laxton, Kellum Friday, Lee Thomas and Mark Thomas.
Ryan Horton will make his debut and there is a recall for Martin Cormack.
Leyland have won all five of their matches so far to top NWML Division Four and are the favourites for the title.
Squad: Benji Marsh,Chris Young,Declan Foy, Dan Timperley, Johnny Rae, Kellum Friday, Lee Thomas, Luke Harrison, Mark Kingsley, Mark Thomas, Martin Cormack, Olly Laxton, Ryan Horton, Simon Quinn, Stuart Davies, Tom Bradfield, Will Benson.
Kick off is at 2.30pm and the game is taking place at The Cheshire County Sports Club, Plas Newton Lane, Chester CH2 1PR.