Grantham will be buoyed by the impressive 5-1 victory over Whitby on Thursday, which saw goals from Danny Meadows, Sam Osborne, Andrew Wright and a brace from Jordan Hempenstall secure the three points for the Gingerbreads.
The result left Grantham in 3rd place and now just three points away from sealing a play-off place after other results going in their favour during the week.
Table toppers Altrincham meanwhile travel to the Meres on Saturday knowing that just one point will secure them the title. This follows on from the Robins' 2-1 win away at Shaw Lane on Thursday, which saw them move eight points clear at the top - putting them in pole position to win the league.
The previous encounter between the two sides earlier in the season saw the Gingerbreads fall to a controversial 1-0 defeat away from home and they will be looking to spoil Altrincham's promotion party.
Grantham boss Adam Stevens has said his side can't let the occasion get to them on Saturday as they prepare for a tough test: "Sealing a play-off place would be the icing on the cake to a brilliant season but we have to make sure we win the game first. Altrincham will have a big support coming down and will want to wrap up the title for them so we must be play as we have been all season and prepare ourselves for a very tough game this weekend."
Captain Stefan Galinski could be doubtful for Saturday after picking up an injury on Thursday which saw him substituted for Michael Hollingsworth. Luke Shaw is still also unavailable due to injury. The rest of the squad is available for selection.