There are four changes to the starting 15 that lost to Bishop Auckland last week.
In the backs, Dean Ryan and David Chester both come in while Carl Hanson for Joe Myers is the only change to the starting pack.
Ryan lines up on the wing with Antony Lawrence moving to full back to replace Lewis Wilson.
Keagan Thomas has struggled to shake off a niggling shoulder injury so Chester, who scored a brace of tries for Hartlepool A last time out, starts alongside Adam Ainley in the centre.
Tyler Hall and Shane Ivey both come into the squad and will be hoping to make an impact from the bench.
T Stead, Small (c), Williamson, Johnson, Hanson, Kitching, Carney, Dickson, P Wilson, Lister, Ryan, Ainley, Chester, Drewett, Lawrence
Reps: N Stead, S Ivey, Hall
Hartlepool A are on the road for only the second time this year following a run of home games. They travel to Blackwell Meadows for a County Cup quarter final tie with Darlington.
The visitors go into the game buoyed by consecutive home victories over Medicals and Bishop Auckland in the CANDY League, and will be hoping to navigate this tricky Cup fixture to secure a semi final berth.