Lee Casswell's men have been drawn away to Evo-Stik NPL Premier Division side Rushall Olympic.
The Pics are currently in the top ten of the top tier and Leek have have had a pretty dreadful record against them in all competitions over the years.
In the other semi-final Rocester or Kidsgrove Athletic will take on Hednesford Town.
The ties are scheduled to take place in the week commencing Monday 7th March, but th exact date is yet to be confirmed.