Boro earned their first win of 2016 in a hard-fought battle at Brackley and showed that there is a fair amount of spirit to go along with the undoubted quality in Kevin Wilson's team this campaign.
Things didn't start well for the visitors - the game was less than a minute old when Lowe let rip with a stunning side-footed finish that left Jordan Smith with no chance.
Boro regrouped well and immediately took the game to their hosts. They soon found a foothold in proceedings and were rewarded in the 14th minute when Shane Byrne drew them level.
The Boro skipper found room on the edge of the box and struck his shot well, it took a deflection, though, to leave Brackley keeper Sam Hornby with no chance as it skidded over his leg and into the back of the net.
Neither keeper was tested after that as the first half ended with both teams working hard, but unable to add to the score, though James Clifton did see an effort go wide when he was through on goal.
HT: Brackley 1 Nuneaton Town 1
Despite the stop-start nature of the game, Boro were still managing to be the more attack minded of the two sides and it was a deserved second goal that came their way early in the second half.
A run from Tyrell Waite saw him power into the box where he crossed to Elliott Whitehouse who did the rest with a header into the far corner of the net.
The Boro looked in control at this point so it was a surprise when Brackley drew level not long after, the goal itself being somewhat fortunate for the home side, though.
There appeared to be little danger when David Morgan picked the ball up in his own box. However, his attempted clearance cannoned back off Richard Batchelor and fizzed straight past Jordan Smith and into the net.
Despite the set-back Boro continued to push forward and once again their talisman – Elliott Whitehouse – came up with the goods at the right time.
His first goal was about being in the right place at the right time, his second, Nuneaton's third, was all about ability, as the number ten was found on the edge of the box by debutant Wes McDonald.
Whitehouse turned and smashed an unstoppable effort past Hornby to give the away side the lead once again.
It proved to be the final goal of the game as Boro withstood some late pressure to finally bring to an end their winless run this year.
FT: Brackley 2 Nuneaton Town 3
BRACKLEY TOWN: Hornby, English, McDonald, Clarke, Slade, Mills (Ndlovu 87), Lowe, Walker, Moyo, Diggin, Batchelor (Cameron 82).
Subs not used: Marsden, Winters, Graham.
NUNEATON TOWN: J.Smith, Clifton, C.Keane, Morgan, J.Keane (Maguire 68), Rowe-Turner, Waite, Byrne, Harewood (Ironside 63), Whitehouse, McDonald (Warburton 87).
Subs not used: Duffy, Daniels.