Contests between the two sides are invariably close with the Bramhope men edging through by 4 points both home and a\way in the two league encounters last season.
The Wortley men had a good run in the competition last season, going out 14 v 0 to eventual winners Ilkley in the semi final but qualifying for the National Senior Vase in the process.
The visitors are reported to have had a good pre-season and will arrive in determined mood.
The hosts are likely to field a mainly familiar looking line up although several new recruits are poised to make their debuts.
There is further home action when a West Park Leeds squad host Wibsey 1st XV.
Both games kick off at 3pm.