| Sunday 21st March 2010 | ||||||
| Raunds Town LFC | vs | Oadby & Wigston LFC | 14:00 | |||
| Asfordby Amateurs LFC | vs | Sleaford Town LFC | 14:00 | |||
| Barrowby Ladies FC | vs | Nuneaton Town LFC | 14:00 | |||
| Daventry Town LFC | vs | Long Eaton United LFC | 14:00 | |||
| Hinckley United LFC | vs | Huncote Sports & Social LFC | 14:00 | |||
| Sunday 28th March 2010 | ||||||
| Sleaford Town LFC | vs | Nuneaton Town LFC | 14:00 | |||
| Huncote Sports & Social LFC | vs | Barrowby Ladies FC | 14:00 | |||
| Oadby & Wigston LFC | vs | Hinckley United LFC | 14:00 | |||
| Raunds Town LFC | vs | Daventry Town LFC | 14:00 | |||
| Asfordby Amateurs LFC | vs | Kingsthorpe Ladies FC | 14:00 | |||
| Wednesday 31st March 2010 | ||||||
| Huncote Sports & Social LFC | vs | Nuneaton Town LFC | 19:30 | |||
| Sunday 4th April 2010 | ||||||
| Raunds Town LFC | vs | Barrowby Ladies FC | 14:00 | |||
| Nuneaton Town LFC | vs | Daventry Town LFC | 14:00 | |||
| Kingsthorpe Ladies FC | vs | Sleaford Town LFC | 14:00 | |||
| Oadby & Wigston LFC | vs | Asfordby Amateurs LFC | 14:00 | |||
| Long Eaton United LFC | vs | Huncote Sports & Social LFC | 14:00 | |||
| Sunday 11th April 2010 | ||||||
| Asfordby Amateurs LFC | vs | Huncote Sports & Social LFC | 14:00 | |||
| Barrowby Ladies FC | vs | Raunds Town LFC | 14:00 | |||
| Sleaford Town LFC | vs | Oadby & Wigston LFC | 14:00 | |||
| Long Eaton United LFC | vs | Nuneaton Town LFC | 14:00 | |||
| Wednesday 14th April 2010 | ||||||
| Kingsthorpe Ladies FC | vs | Nuneaton Town LFC | 19:30 | |||
| Long Eaton United LFC | vs | Hinckley United LFC | 19:30 | |||
| Asfordby Amateurs LFC | vs | Oadby & Wigston LFC | 19:30 | |||
| Sunday 18th April 2010 | ||||||
| Nuneaton Town LFC | vs | Barrowby Ladies FC | 14:00 | |||
| Sleaford Town LFC | vs | Asfordby Amateurs LFC | 14:00 | |||
| Kingsthorpe Ladies FC | vs | Long Eaton United LFC | 14:00 | |||
| Daventry Town LFC | vs | Hinckley United LFC | 14:00 | |||
| Wednesday 21st April 2010 | ||||||
| Oadby & Wigston LFC | vs | Nuneaton Town LFC | 19:30 | |||
| Hinckley United LFC | vs | Barrowby Ladies FC | 19:30 | |||
| Sunday 2nd May 2010 | ||||||
| Barrowby Ladies FC | vs | Oadby & Wigston LFC | 14:00 | |||
| Huncote Sports & Social LFC | vs | Daventry Town LFC | 14:00 | |||
| Sleaford Town LFC | vs | Kingsthorpe Ladies FC | 14:00 | |||
| Nuneaton Town LFC | vs | Long Eaton United LFC | 14:00 | |||
| Sunday 9th May 2010 | ||||||
| Nuneaton Town LFC | vs | Kingsthorpe Ladies FC | 14:00 | |||
| Raunds Town LFC | vs | Huncote Sports & Social LFC | 14:00 | |||
| Asfordby Amateurs LFC | vs | Daventry Town LFC | 14:00 | |||
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Division 1 South - Fixtures