Having been soundly beaten by joint leaders Orrell St James last week, Chester were out to make amends and produced a much improved performance.
The Gladiators were only six points behind until the final 10 minutes when Wigan scored two quick tries to seal the win and maintain their 100 per cent to the season.
Chester have now suffered three straight defeats but their opponents currently occupy the top three places in division four of the North West Men's League.
The game started brightly with both sides prepared to move the ball around the pitch but it was Wigan who drew first blood with a converted try on eight minutes.
Chester responded well and some good work by captain Dan Rowett saw him offload to veteran Paul Foster who touched down under the posts to level the scores.
Wigan hit back strongly and pushed hard in search of another score but some resolute Chester defence kept the Bulldogs at bay.
However, the visitors did eventually managed to force their way over the line for a second try to lead 12-6 at the interval.
Wigan struck first in the second half to move 18-6 in front but the Gladiators refused to lie down and replied with the try of the game.
Debutant winger Tomasi Qera beat two defenders before chipping through and collecting his own kick for a fine solo try which brough Chester to within six points.
The Gladiators continued to press strongly with some good runs by Michael Durham and Luke Edwards, and had some decent chances to level the match.
But Wigan were in no mood to give up their lead and defended well, although Chester were guilty of failing to take full advantage of the opportunities that came their way.
Crucially it was the Bulldogs who were next to score as Chester spilled the ball allowing the visitors to turn defence into attack to move 24-12 ahead.
Chester continued to work hard to find a way into the game but tiredness began to play its part and it was Wigan who wrapped up the win with the final try of the match.
The Gladiators will take plenty of confidence from their performance against a team who are likely to be serious title contenders.
Chester travel to Little Hulton Reds next week. The next home game is against Westhoughton Lions on Saturday, May 4.