Newmarket will head to Mersea Island with the hope of reeling in the teams above them in the table.
They are second from bottom but only seven points behind Mersea, who are fourth from bottom, with two games remaining.
Danny Brookes, Pat Kearney and Matt Kent are all missing for the trip, but head coach Dave Sayer will take his troops to Mersea in optimistic mood.
"We lose a bit of height in the line-out (without Matt Kent) but we can get round that and run some moves with that in mind," said Sayer.
"I will do some one-on-ones with the team on the bus going down there and give them a bit of encouragement.
"I don't know much about Mersea so we will try to run the ball and work on the fitness. We have to score early and shut the crowd up as quickly as we can.
"It's a matter of playing simple rugby and adding the points and building the score as we go."
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